Humacyte (NASDAQ:HUMA – Get Free Report) and Entera Bio (NASDAQ:ENTX – Get Free Report) are both small-cap medical companies, but which is the better business? We will contrast the two companies based on the strength of their institutional ownership, analyst recommendations, profitability, valuation, earnings, risk and dividends.
Risk & Volatility
Humacyte has a beta of 1.47, meaning that its share price is 47% more volatile than the S&P 500. Comparatively, Entera Bio has a beta of 1.57, meaning that its share price is 57% more volatile than the S&P 500.
Analyst Ratings
This is a summary of current ratings and recommmendations for Humacyte and Entera Bio, as reported by MarketBeat.com.
| Sell Ratings | Hold Ratings | Buy Ratings | Strong Buy Ratings | Rating Score | |
| Humacyte | 0 | 1 | 4 | 1 | 3.00 |
| Entera Bio | 0 | 0 | 1 | 0 | 3.00 |
Profitability
This table compares Humacyte and Entera Bio’s net margins, return on equity and return on assets.
| Net Margins | Return on Equity | Return on Assets | |
| Humacyte | N/A | -942.81% | -79.04% |
| Entera Bio | N/A | -100.37% | -84.09% |
Insider and Institutional Ownership
44.7% of Humacyte shares are held by institutional investors. Comparatively, 14.1% of Entera Bio shares are held by institutional investors. 23.1% of Humacyte shares are held by company insiders. Comparatively, 10.9% of Entera Bio shares are held by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company will outperform the market over the long term.
Valuation & Earnings
This table compares Humacyte and Entera Bio”s revenue, earnings per share (EPS) and valuation.
| Gross Revenue | Price/Sales Ratio | Net Income | Earnings Per Share | Price/Earnings Ratio | |
| Humacyte | $1.57 million | 394.42 | -$110.78 million | ($1.00) | -5.20 |
| Entera Bio | $57,000.00 | 1,274.45 | -$8.89 million | ($0.28) | -7.25 |
Entera Bio has lower revenue, but higher earnings than Humacyte. Entera Bio is trading at a lower price-to-earnings ratio than Humacyte, indicating that it is currently the more affordable of the two stocks.
Summary
Humacyte beats Entera Bio on 7 of the 13 factors compared between the two stocks.
About Humacyte
Humacyte, Inc. engages in the development and manufacture of off-the-shelf, implantable, and bioengineered human tissues for the treatment of diseases and conditions across a range of anatomic locations in multiple therapeutic areas. The company using its proprietary and scientific technology platform to engineer and manufacture human acellular vessels (HAVs) to be implanted into patient without inducing a foreign body response or leading to immune rejection. It is developing a portfolio of HAVs, which would target the vascular repair, reconstruction, and replacement market, including vascular trauma; arteriovenous access for hemodialysis; peripheral arterial disease; pediatric heart surgery; and coronary artery bypass grafting, as well as for the delivery of cellular therapy, including pancreatic islet cell transplantation to treat Type 1 diabetes. The company was founded in 2004 and is headquartered in Durham, North Carolina.
About Entera Bio
Entera Bio Ltd., a clinical-stage company, focuses on the development and commercialization of orally delivered peptide and protein therapeutics for unmet medical needs. The company's product candidates include the EB612, which is in Phase II clinical trials for the treatment of hypoparathyroidism; and EB613 that has completed Phase II clinical trials for the treatment of osteoporosis, as well as is in Phase I clinical trials for the treatment of stress fractures. Its other product candidate is GLP-2, which is in preclinical trial for the treatment of short bowl syndrome; and OXM for the treatment of obesity and metabolic diseases. The company has a research collaboration and license agreement with the Amgen Inc. for the development and discovery of clinical candidates in the field of inflammatory disease and other serious illnesses. Entera Bio Ltd. was incorporated in 2009 and is based in Jerusalem, Israel.
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