Curis (NASDAQ:CRIS – Get Free Report) and ImmunityBio (NASDAQ:IBRX – Get Free Report) are both medical companies, but which is the superior investment? We will compare the two companies based on the strength of their profitability, risk, analyst recommendations, earnings, institutional ownership, valuation and dividends.
Profitability
This table compares Curis and ImmunityBio’s net margins, return on equity and return on assets.
| Net Margins | Return on Equity | Return on Assets | |
| Curis | -443.35% | -923.37% | -78.35% |
| ImmunityBio | -8,016.83% | N/A | -110.02% |
Institutional & Insider Ownership
30.0% of Curis shares are owned by institutional investors. Comparatively, 8.6% of ImmunityBio shares are owned by institutional investors. 5.7% of Curis shares are owned by insiders. Comparatively, 83.4% of ImmunityBio shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a company will outperform the market over the long term.
Analyst Recommendations
| Sell Ratings | Hold Ratings | Buy Ratings | Strong Buy Ratings | Rating Score | |
| Curis | 0 | 0 | 3 | 0 | 3.00 |
| ImmunityBio | 0 | 1 | 3 | 1 | 3.00 |
Curis currently has a consensus price target of $23.00, suggesting a potential upside of 891.38%. ImmunityBio has a consensus price target of $12.19, suggesting a potential upside of 288.14%. Given Curis’ higher probable upside, equities analysts clearly believe Curis is more favorable than ImmunityBio.
Valuation and Earnings
This table compares Curis and ImmunityBio”s top-line revenue, earnings per share (EPS) and valuation.
| Gross Revenue | Price/Sales Ratio | Net Income | Earnings Per Share | Price/Earnings Ratio | |
| Curis | $10.26 million | 1.91 | -$47.41 million | ($7.81) | -0.30 |
| ImmunityBio | $14.75 million | 181.74 | -$583.20 million | ($0.63) | -4.98 |
Curis has higher earnings, but lower revenue than ImmunityBio. ImmunityBio is trading at a lower price-to-earnings ratio than Curis, indicating that it is currently the more affordable of the two stocks.
Volatility and Risk
Curis has a beta of 3.49, indicating that its share price is 249% more volatile than the S&P 500. Comparatively, ImmunityBio has a beta of 0.82, indicating that its share price is 18% less volatile than the S&P 500.
Summary
Curis beats ImmunityBio on 7 of the 13 factors compared between the two stocks.
About Curis
Curis, Inc., a biotechnology company, engages in the discovery and development of drug candidates for the treatment of human cancers in the United States. Its clinical stage drug candidates include Emavusertib, an oral small molecule IRAK4 kinase inhibitor, which is in a Phase 1/2 open-label, single arm expansion trial in patients with relapsed or refractory, or R/R, AML and high-risk myelodysplastic syndromes. The company’s pipeline also includes Fimepinostat, an oral dual inhibitor of HDAC and PI3K enzymes for the treatment of patients with relapsed or refractory diffuse large B-cell lymphoma; CA-170, an oral, small molecule antagonist designated as CA-170 that selectively targets PD-L1 and VISTA; and CA-327, an oral, small molecule, TIM3/PD-L1, which is a molecule antagonist of PD-L1 and TIM3. It has collaboration agreement with Genentech Inc., or Genentech and F. Hoffmann-La Roche Ltd, or Roche, for the commercialization of Erivedge, an orally-administered small molecule hedgehog signaling pathway antagonist for the treatment of advanced basal cell carcinoma, or BCC; Aurigene Discovery Technologies Limited for the discovery, development, and commercialization of small molecule compounds in the areas of immuno-oncology and precision oncology; and also licensed four programs under the Aurigene collaboration, including emavusertib. Curis, Inc. was incorporated in 2000 and is headquartered in Lexington, Massachusetts.
About ImmunityBio
ImmunityBio, Inc., a clinical-stage biotechnology company, engages in developing therapies and vaccines that bolster the natural immune system to defeat cancers and infectious diseases. Its platforms for the development of biologic product candidates include antibody-cytokine fusion proteins; DNA, RNA, and recombinant protein vaccines; and cell therapies. The company's platforms have generated therapeutic agents that are currently being or planned to be studied in clinical trials across various indications in liquid and solid tumors, including bladder, lung and colorectal cancers, and glioblastoma multiforme. Its lead biologic product candidate is Anktiva, an FDA-approved immunotherapy in combination with bacillus calmette-guérin (BCG) for the treatment of adult patients with BCG unresponsive non-muscle invasive bladder cancer with carcinoma in situ, with or without papillary tumors. The company has collaboration agreements with National Cancer Institute. It also has license agreements with 3M Innovative Properties Company; Access to Advanced Health Institute; LadRx Corporation; Sanford Health; Shenzhen Beike Biotechnology Co. Ltd.; Viracta Therapeutics, Inc.; and GlobeImmune, Inc. The company is based in San Diego, California.
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